TMP269
- Product Name
- TMP269
- CAS No.
- 1314890-29-3
- Chemical Name
- TMP269
- Synonyms
- TMP269;CS-1345;TMP269, >=98%;TMP 269; TMP-269;TMP269 TMP-269 HDACIIa Inhibitor;N-((4-(4-Phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)-3-(5-(trifluoromethyl)-1,2,4-oxad;N-{[4-(4-phenyl-1,3-thiazol-2-yl)oxan-4-yl]methyl}-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide;N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)Methyl)-3-(5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl)benzaMide;N-[[Tetrahydro-4-(4-phenyl-2-thiazolyl)-2H-pyran-4-yl]methyl]-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide;BenzaMide, N-[[tetrahydro-4-(4-phenyl-2-thiazolyl)-2H-pyran-4-yl]Methyl]-3-[5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl]-
- CBNumber
- CB82667421
- Molecular Formula
- C25H21F3N4O3S
- Formula Weight
- 514.52
- MOL File
- 1314890-29-3.mol
TMP269 Property
- Density
- 1.347±0.06 g/cm3(Predicted)
- storage temp.
- Amber Vial, -20°C Freezer, Under inert atmosphere
- solubility
- ≥23 mg/mL in DMSO; insoluble in H2O; ≥21 mg/mL in EtOH with ultrasonic
- form
- solid
- pka
- 13.66±0.46(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 17738
- Product name
- TMP269
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 17738
- Product name
- TMP269
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $151
- Updated
- 2024/03/01
- Product number
- 17738
- Product name
- TMP269
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $266
- Updated
- 2024/03/01
- Product number
- T460000
- Product name
- TMP269
- Packaging
- 5mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- A8806
- Product name
- TMP269
- Packaging
- 5mg
- Price
- $110
- Updated
- 2021/12/16
TMP269 Chemical Properties,Usage,Production
Uses
TMP269 is a selective class IIa histone deacetylase (HDAC) inhibitor via a non chelating zinc-binding group.
Biological Activity
tmp269 is a novel and selective inhibitor of class iia histone deacetylase with ic50 values of 126, 80, 36, 9 nm for hdac 4, 5, 7, 9, respectively [1].histone deacetylases (hadc) are a series of enzymes that remove acetyl groups from an ε-n-acetyl lysine amino acid on a histone and make the histones to wrap the dna more tightly, which prevent transcription.tmp269 is a novel and selective class iia hdac inhibitor. in mm cell lines, tmp269 induced modest cytotoxicity with ic50 values ranging from 22 to 38 μm in a dose-dependent way, which was associated with cleavage of caspase-3, -8, -9 and parp. also, tmp269 enhanced cfz-induced apoptosis and increased the expression of activating transcription factor 4 (atf4) and proapoptotic transcription factor c/ebp homologous protein (chop). in the presence of bmscs or il-6, tmp269 and cfz also showed significant cytotoxicity [2]. in iec-18 intestinal epithelial cells, tmp269 inhibited cell proliferation, cell cycle progression and dna synthesis in response to g protein-coupled receptor/protein kinase d1 (pkd1) activation [3].
target
HDAC9
References
[1]. lobera m, madauss kp, pohlhaus dt, et al. selective class iia histone deacetylase inhibition via a nonchelating zinc-binding group. nat chem biol, 2013, 9(5): 319-325.
[2]. kikuchi s, suzuki r, ohguchi h, et al. class iia hdac inhibition enhances er stress-mediated cell death in multiple myeloma. leukemia, 2015.
[3]. sinnett-smith j, ni y, wang j, et al. protein kinase d1 mediates class iia histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells: role in mitogenic signaling. am j physiol cell physiol, 2014, 306(10): c961-71.
TMP269 Preparation Products And Raw materials
Raw materials
Preparation Products
TMP269 Suppliers
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- +1 (732)236-3202
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View Lastest Price from TMP269 manufacturers
- Product
- TMP269 1314890-29-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 20kg
- Release date
- 2019-09-03